AKTİVE PROTEİN C (APC) RE... - Meaning | Sozluksu

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AKTİVE PROTEİN C (APC) REZİSTANSI
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AKTİVE PROTEİN C (APC) REZİSTANSI (Noun)
(Medicine and Hematology Glossary) :
Faktör V genindeki bir nokta mutasyonu sonucu oluşan ve tromboz eğilimi ile seyreden bir hastalık. Bozuk gendeki amino asit dizliminde 506. sırada arg yerine Gln gelmiştir. APC rezistansının toplumdaki prevalansı %3-5 arası bildirilmektedir. Normal hemostatik süreç içinde, FVa ve FVIIIa protein C'nin aktif formu (APC) tarafından inhibe edilirler. Mutasyona uğrayan FV molekülü bu inhibisyondan etkilenmez. Sonuçta tromboz eğilimi ortaya çıkar.

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