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AKUT LÖSEMİLER

"
Medicine and Hematology Glossary

AKUT LÖSEMİLER (Proper noun)

(Medicine and Hematology Glossary) :
Akut lösemiler hematopoetik progenitör hücrelerin neoplastik transformasyonu ve klonal proliferasyonu sonucu kemik iliğinde immatür hücrelerin artışıyla oluşan hastalıklardır. Akut lösemi tanısı için kemik iliğinde en az 500 hücre sayıldığında toplam çekirdekli hücrelerin %30 veya fazlası oranında blast bulunmalıdır. Tedavi edilmezlerse ölümle sonlanan hastalıklardır. Akut lösemiler akut lenfoblastik lösemi (ALL) veya akut myeloblastik lösemi (AML) olarak iki ana gruba ayrılır. AML olarak adlandırılan lösemiler arasında eritroid, monositik ve megakaryositik lösemiler de yer aldığı için AML yerine akut non lenfositik lösemi (ANLL) denilmesi daha doğrudur, ancak AML daha sık kullanılır. Morfoloji, histokimya, immünoloji ve elktron mikroskop incelemelerine karşın sınıfı belirlenemeyen akut lösemilere akut undiferansiye lösemi (AUL) denir. Bir lösemi hücresinde hem myeloid hem lenfosit işaretler varsa bifenotipik lösemi denir. Myeloid antijen taşıyan ALL'ler için My+ ALL denilmektedir. Bazı akut lösemilerde hem lenfoid hem myeloid elemanlar birlikte bulunursa karma (mikst) lösemi olarak bilinir.
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