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BETA-2 MIKROGLOBULIN

"
Medicine and Hematology Glossary

BETA-2 MIKROGLOBULIN (Proper noun)

(Medicine and Hematology Glossary) :
Vücutta tüm çekirdekli hücrelerin membranındaki histokompatibilite antijenlerinin (class I HLA) hafif zinciridir. 11.800 dalton ağırlığında küçük bir polipeptiddir. Membran turnoveri ve hücre ölümü sonucu vücut sıvılarına salınır. Glomerülden filtre olur ve tüplerde katabolize edilir. Serum Beta2 mikroglobulin düzeylerini değerlendirirken, böbrek yetmezliği varsa Beta2 mikroglobulininin yüksek bulunabileceği unutulmamalıdır. Akut ve kronik lösemiler, lenfoproliferatif hastalıklar, myeloproliferatif hastalıklar, myelodisplastik sendrom, otoimmün hastalıklar ve karaciğer hastalıklarında Beta-2 mikroglobulin artabilmektedir. Mide ve bronş karsinomu gibi solid tümörlerde ise Beta-2 mikroglobulin artışı saptanmamıştır.
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