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HİPEREOZİNOFİLİK SENDROM (HES)

"
Medicine and Hematology Glossary

HİPEREOZİNOFİLİK SENDROM (HES) (Noun)

(Medicine and Hematology Glossary) :
En az 6 ay süreyle mutlak eozinofil sayısının 1500/mm3'ün üzerinde seyretmesi ve buna bağlı organ hasarıyla ortaya çıkan bir tablodur. Etyolojisi bilinmiyor. HES tanısı için yukarda belirtilen süre ve eozinofil sayısı yanında eozinofili yapabilecek bir hastalık olmaması, yani idyopatik oluş ve kalp, karaciğer, dalak, santral sinir sistemi, akciğer gibi organ ve dokularda tutulum olması gereklidir. Eozinofil sayısı 100.000'i geçebilir. Ateş, kilo kaybı, anemi sık görülür. Eozinofil granüllerinden serbest hale geçen maddelere bağlı olarak başta kalp ve sinir sistemi olmak üzere çeşitli organ ve dokularda hasar oluşur. Eozinofiller morfolojik olarak normal olabilecekleri gibi hipersegmentasyon, vaküolizasyon gibi morfolojik bozukluklar gösterebilirler. Eozinofilik lösemiden ayırımı gerekir. HES'da periferik kanda eozinofil seriye ait immatür hücreler bulunmaması ayırımda yardımcıdır. Tedavisinde eozinofil sayısının azaltılması hedeflenir ve bu amaçla kortikosteroidler ve hydroxyurea kullanılabilir, lökoforez yaralı olabilir. Semptomatik olarak antihistaminik kullanılabilir. Eozinofilik lösemi tanısı konanlarda akut myelositik lösemi tedavisi yapılır.
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