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HİSTİYOSİTİK LENFOMA

"
Medicine and Hematology Glossary

HİSTİYOSİTİK LENFOMA (Noun)

(Medicine and Hematology Glossary) :
Fagositik histiyositlerin tümörüdür. Histiyositik lenfoma terimi ilk kez Rappaport sınıflamasında yer almış, ancak daha sonraki yıllarda bu hücrelerin çoğunun aslında histiyosit (doku makrofajı) değil lenfoid hücreler olduğu anlaşılmıştır. Bugünkü bilgilere göre gerçek histiyositik lenfoma son derece nadirdir. Doğru tanı için sadece morfoloji değil immünofenotipik ve histokimyasal olarak bu hücrelerin monosit-makrofaj/histiyosit serisine ait olduklarının gösterilmesi gerekir. Malign histiyositosis (MH) ve gerçek histiyositik lenfoma terimleri aynı olmamakla birlikte pratikte aynı hastalık grubunun tanımı için kullanılır. MH'da daha yaygın bir hastalık tablosu vardır. Genel olarak ateş, splenomegali ve sitopenilerle seyreden hızlı gidişli bir klinik tablo vardır. Ekstranodal tutulum sıktır (cilt, GIS, kemik).
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