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HEXOSE MONOFOSFAT METABOLİK YOLU

"
Medicine and Hematology Glossary

HEXOSE MONOFOSFAT METABOLİK YOLU (Proper noun)

(Medicine and Hematology Glossary) :
Eritrosit enerji metabolizmasındaki iki önemli biyokimyasal yoldan birisi. Pentoz fosfat yolu olarak da adlandırılır. Eritrosit içine alınan glukozun %10'luk kısmı Hexose monophosphate yolu ile kullanılır. Bu yolun en önemli enzimi "glukoz 6 fosfat dehidrogenaz"dır (G-6PD). G-6PD enzimi "6-fosfoglukonat dehidrogenaz" ile birlikte G-6-P'ı ribulose-5-fosfat'a çevirir. Bu dönüşüm sırasında da NADP'den NADPH oluşur. NADPH "glutatyon redüktaz" enzimi yardımıyla GSSG'nin redüksiyonunda rol alır. Bu yolun önemli görevi nikotinamid adenin dinükleotid fosfat (NADP)'ın redükte forma (NADPH) dönüştürülmesidir. NADPH eritrosit metabolizmasında çok önemli bir görev yapar. Oksitlenmiş glutatyonun (GSSG) indirgenmesi için gerekli H+ iyonları NADPH'den sağlanır. İndirgenmiş glutatyon (GSH) hemoglobin ve eritrosit membranındaki sülfidril gruplarını peroksid, superoxide ve bazı ilaçların oksidan etkilerine karşı korur. Hexose monophosphate metabolik yolunda görev yapan enzimlerden birisi olan glukoz-6-fosfat dehidrogenaz eksikliğindeki hemolitik aneminin nedeni eritrositin bu tür oksidatif etkilere karşı korunamamasından kaynaklanır.
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