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REZİSTANS
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AKTİVE PROTEİN C (APC) REZİSTANSI
(Medicine and Hematology Glossary) :
Faktör V genindeki bir nokta mutasyonu sonucu oluşan ve tromboz eğilimi ile seyreden bir hastalık. Bozuk gendeki amino asit dizliminde 506. sırada arg yerine Gln gelmiştir. APC rezistansının toplumdaki prevalansı %3-5 arası bildirilmektedir. Normal hemostatik süreç içinde, FVa ve FVIIIa protein C'nin aktif formu (APC) tarafından inhibe edilirler. Mutasyona uğrayan FV molekülü bu inhibisyondan etkilenmez. Sonuçta tromboz eğilimi ortaya çıkar.
REZİSTANS
(Medicine and Hematology Glossary) :
Direnç, mukavemet.
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